Human Molecular Genetics

Cover: X-chromosome inactivation ratios affect wild-type MeCP2 expression within mosaic Rett syndrome and Mecp2^–/+ mouse brain. Laser scanning cytometry images of a female Mecp2^–/+ mouse brain (top) and a wild-type mouse brain (bottom). Pixels represent individual cells colored based on quantitative immunofluorescence of MeCP2: MeCP2-negative (blue), MeCP2^lo (green) and MeCP2^hi (red). Background image is a high-resolution fluorescent micrograph of MeCP2 immunofluorescence (red) and nuclear counterstain (green) within a Mecp2^–/+ mouse cerebrum. Mecp2 mutant-expressing cells affect the expression of wild-type MeCP2 in heterozygous females by a non-cell-autonomous mechanism. See Article by Braunschweig et al., in this issue, pp.1275–1286.

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