Cover: In vivo activation of the extracellular regulated kinase (MAPK/ERK) pathway in autosomal dominant polycystic kidney disease. Immunofluorescence image of a cystic kidney from a mouse with conditional kidney-selective inactivation of Pkd1 at post natal day 7. Increased phospho-ERK1/2 expression (green) is confined to a subset of cells lining the kidney cysts. The collecting duct origin of the cysts is indicated by staining with the lectin Dolichos biflorus (red). Nuclei are marked by DAPI (blue), see Shibazaki et al., pp. 1505-1516.
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